Wasko, M. J., Witt-Enderby, P. A. & Surratt, C. K. DARK classics in chemical neuroscience: ibogaine. ACS Chem. Neurosci. 9, 2475–2483 (2018).
Noller, G. E., Frampton, C. M. & Yazar-Klosinski, B. Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study. Am. J. Drug Alcohol Abuse 44, 37–46 (2018).
He, D. Y. et al. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J. Neurosci. 25, 619–628 (2005).
Marton, S. et al. Ibogaine administration modifies GDNF and BDNF expression in brain regions involved in mesocorticolimbic and nigral dopaminergic circuits. Front. Pharmacol. 10, 193 (2019).
Jenks, C. W. Extraction studies of Tabernanthe iboga and Voacanga africana. Nat. Prod. Lett. 16, 71–76 (2002).
Iyer, R. N., Favela, D., Zhang, G. & Olson, D. E. The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs. Nat. Prod. Rep. https://doi.org/10.1039/D0NP00033G (2020).
Hough, L. B., Pearl, S. M. & Glick, S. D. Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration. Life Sci. 58, PL119–PL122 (1996).
Koenig, X., Kovar, M., Boehm, S., Sandtner, W. & Hilber, K. Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk. Addict. Biol. 19, 237–239 (2014).
Thurner, P. et al. Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. J. Pharmacol. Exp. Ther. 348, 346–358 (2014).
Alper, K. R., Stajić, M. & Gill, J. R. Fatalities temporally associated with the ingestion of ibogaine. J. Forensic Sci. 57, 398–412 (2012).
Koenig, X. & Hilber, K. The anti-addiction drug ibogaine and the heart: a delicate relation. Molecules 20, 2208–2228 (2015).
Baumann, M. H., Pablo, J. P., Ali, S. F., Rothman, R. B. & Mash, D. C. Noribogaine (12-hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine. Ann. NY Acad. Sci. 914, 354–368 (2000).
Olson, D. E. Psychoplastogens: a promising class of plasticity-promoting neurotherapeutics. J. Exp. Neurosci. 12, 1179069518800508 (2018).
Ly, C. et al. Psychedelics promote structural and functional neural plasticity. Cell Rep. 23, 3170–3182 (2018).
Bogenschutz, M. P. & Johnson, M. W. Classic hallucinogens in the treatment of addictions. Prog. Neuropsychopharmacol. Biol. Psychiatry 64, 250–258 (2016).
Wender, P. A., Verma, V. A., Paxton, T. J. & Pillow, T. H. Function-oriented synthesis, step economy, and drug design. Acc. Chem. Res. 41, 40–49 (2008).
Gassaway, M. M. et al. Deconstructing the iboga alkaloid skeleton: potentiation of FGF2-induced glial cell line-derived neurotrophic factor release by a novel compound. ACS Chem. Biol. 11, 77–87 (2016).
Wager, T. T., Hou, X., Verhoest, P. R. & Villalobos, A. Central nervous system multiparameter optimization desirability: application in drug discovery. ACS Chem. Neurosci. 7, 767–775 (2016).
Glennon, R. A., Young, R., Jacyno, J. M., Slusher, M. & Rosecrans, J. A. DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. Eur. J. Pharmacol. 86, 453–459 (1983).
Dunlap, L. E. et al. Identification of psychoplastogenic N,N-dimethylaminoisotryptamine (isoDMT) analogs through structure–activity relationship studies. J. Med. Chem. 63, 1142–1155 (2020).
Halberstadt, A. L., Chatha, M., Klein, A. K., Wallach, J. & Brandt, S. D. Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology 167, 107933 (2020).
McCarroll, M. N. et al. Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nat. Commun. 10, 4078 (2019).
Breuer, L. et al. “Herbal seizures” – atypical symptoms after ibogaine intoxication: a case report. J. Med. Case Rep. 9, 243 (2015).
Dach, K. et al. Teratological and behavioral screening of the national toxicology program 91-compound library in zebrafish (Danio rerio). Toxicol. Sci. 167, 77–91 (2019).
Rothman, R. B. & Baumann, M. H. Serotonergic drugs and valvular heart disease. Expert Opin. Drug Saf. 8, 317–329 (2009).
Phoumthipphavong, V., Barthas, F., Hassett, S., Kwan, A. C. Longitudinal effects of ketamine on dendritic architecture in vivo in the mouse medial frontal cortex. eNeuro 3, 0133-15 (2016).
Moda-Sava, R. N. et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science 364, eaat8078 (2019).
Cameron, L. P. & Olson, D. E. Dark classics in chemical neuroscience: N,N-dimethyltryptamine (DMT). ACS Chem. Neurosci. 9, 2344–2357 (2018).
Warnault, V., Darcq, E., Levine, A., Barak, S. & Ron, D. Chromatin remodelling — a novel strategy to control excessive alcohol drinking. Transl. Psychiatry 3, e231 (2013).
Glick, S. D. et al. Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Res. 657, 14–22 (1994).
Giannotti, G., Barry, S. M., Siemsen, B. M., Peters, J. & McGinty, J. F. Divergent prelimbic cortical pathways interact with BDNF to regulate cocaine-seeking. J. Neurosci. 38, 8956–8966 (2018).
Glick, S. D., Kuehne, M. E., Maisonneuve, I. M., Bandarage, U. K. & Molinari, H. H. 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain Res. 719, 29–35 (1996).
Carnicella, S., He, D. Y., Yowell, Q. V., Glick, S. D. & Ron, D. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addict. Biol. 15, 424–433 (2010).
Bandarage, U. K., Kuehne, M. E. & Glick, S. D. Total syntheses of racemic albifloranine and its anti-addictive congeners, including 18-methoxycoronaridine. Tetrahedron 55, 9405–9424 (1999).
Langheinrich, U., Vacun, G. & Wagner, T. Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicol. Appl. Pharmacol. 193, 370–382 (2003).
Sampurna, B. P., Audira, G., Juniardi, S., Lai, Y.-H. & Hsiao, C.-D. A simple ImageJ-based method to measure cardiac rhythm in zebrafish embryos. Inventions 3, 21 (2018).
Westerfield, M. The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio) 5th edn (Univ. Oregon Press, 2007).
Ahrens, M. B., Orger, M. B., Robson, D. N., Li, J. M. & Keller, P. J. Whole-brain functional imaging at cellular resolution using light-sheet microscopy. Nat. Methods 10, 413–420 (2013).
Kroeze, W. K. et al. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat. Struct. Mol. Biol. 22, 362–369 (2015).
Barupal, D. K. et al. A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the international mouse phenotyping consortium. Metabolites 9, 101 (2019).
Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28, 41–51 (2000).
Xu, T. et al. Rapid formation and selective stabilization of synapses for enduring motor memories. Nature 462, 915–919 (2009).
Chen, C. C., Lu, J., Yang, R., Ding, J. B. & Zuo, Y. Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects. Mol. Psychiatry 23, 1614–1625 (2018).
Vazquez, M., Frazier, J. H., Reichel, C. M. & Peters, J. Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking. Learn. Mem. 27, 6–11 (2020).